Understanding THC Tolerance & Absorption

The effects of Delta-9 THC can vary significantly between individuals and even between different occasions for the same individual. This variability is influenced by several biological factors:

Metabolism & Absorption: When THC is ingested, it is metabolized by the liver into 11-hydroxy-THC, a compound that can cross the blood-brain barrier more easily, potentially leading to more intense effects. The rate and efficiency of this conversion can vary based on individual metabolic rates, the presence of certain enzymes, and the speed at which THC passes through the digestive system. Factors such as diet, hydration, and overall health can influence this process.

First-Pass Metabolism: Orally consumed THC undergoes first-pass metabolism in the liver, where it is converted into 11-hydroxy-THC. This process can result in a more potent and longer-lasting effect compared to inhalation methods, as 11-hydroxy-THC has a higher affinity for cannabinoid receptors in the brain. However, the extent of this conversion can vary among individuals due to genetic differences and liver enzyme activity.

Biological Variability: Genetic factors can affect how liver enzymes metabolize THC into 11-hydroxy-THC. Variations in genes coding for cytochrome P450 enzymes, which are involved in drug metabolism, can influence individual responses to cannabis. Age and overall liver function also play roles in this metabolic process.

Tolerance Fluctuations: Regular use of THC can lead to the development of tolerance, where the body becomes less responsive to the same dose over time. Interestingly, even after a tolerance break, the same dose may not provide identical effects due to other internal and external factors influencing the body’s response.

Given these variables, it’s common for individuals to experience different effects from the same dose on different occasions. At Bitola Organics, we ensure consistent formulations across all our products. However, individual experiences may vary due to the complex nature of THC metabolism and absorption.